Thursday, November 28, 2013

Scientists grow human liver from stem cells, hope to relieve transplant woes (video)

Scientists grow human liver from stem cells, hope to relieve transplant woes (video) data = {blogUrl: "",v: 400};when = {jquery: lab.scriptBs("jquery"),plugins: lab.scriptBs("plugins"),eng: lab.scriptBs("eng")}; var s265prop9 = ('20648887' !== '') ? 'bsd:20648887' : ''; var postID = '20648887'; var modalMNo = '93319231', modalVideoMNo = '93320648', modalGalleryMNo = '93304207'; when.eng("eng.omni.init", {pfxID:"weg",pageName:document.title,server:"",channel:"us.engadget", s_account: "aolwbengadget,aolsvc", short_url: "",pageType:"",linkInternalFilters:"javascript:,",prop1:"article",prop2:"science",prop9:s265prop9,prop12:document.location,prop17:"",prop18:"",prop19:"",prop20:"", prop22:"nicole-lee", prop54:"blogsmith",mmxgo: true }); adSendTerms('1')adSetMOAT('1');adSetAdURL('/_uac/adpagem.html');lab._script("").wait(function(){var floatingAd = new AdhesiveAd("348-14-15-13c",{hideOnSwipe:true});}); onBreak({980: function () { adSetType("F");htmlAdWH("93319231", "LB", "LB"); adSetType("");}}); EngadgetMenu NewsReviews Features Galleries VideosEventsPodcasts Engadget ShowTopics Buyers Guides Sagas Store Hands On More Betterer HD Mobile Alt Announcements Cameras Cellphones Desktops Displays Gaming GPS Handhelds Home Entertainment Household Internet Laptops Meta Misc Networking Peripherals Podcasts Robots Portable Audio/Video Science Software Storage Tablets Transportation Wearables Wireless Acer Amazon AMD Apple ASUS AT&T Blackberry Canon Dell Facebook Google HP HTC Intel Lenovo LG Microsoft Nikon Nintendo Nokia NVIDIA Samsung Sony Sprint T-Mobile Verizon About UsSubscribeLike Engadget@engadgettip uswhen.eng("eng.nav.init")when.eng("") onBreak({980: function () {htmlAdWH("93310027", "215", "35",'AJAX','ajaxsponsor');}});Scientists grow human liver from stem cells, hope to relieve transplant woes (video) AltBypostedJul 4th, 2013 at 5:09 AM 0

Stem cells used to create human liver tissue

Stem cell research has resulted in several important breakthroughs in medicine, such as rebuilding the larynx and regenerating spinal cord connectors. Now the liver, one of the most highly sought after organs on the donor transplant list, could get some serious stem cell assistance as well. A team of scientists led by Takanori Takebe of Yokohama City University has successfully created a miniature version of the human liver with the help of induced pluripotent stem cells (iPSC), which are derived from adult somatic cells. They developed the iPSC into generalized liver cells called hepatocytes, at which point the researchers mixed in endothelial cells and mesenchymal stem cells, left the petri dishes alone for a couple days, and voila -- an extremely tiny version of a human liver, said to be the first-ever functional human organ grown from stem cells, was born.

The liver "buds," as they're known, measure five millimeters long and are the sort you would find in human embryos shortly after fertilization. When implanted in mice, the baby livers managed to perform all the functions of their adult equivalents. The researchers' next step would be to generate liver buds that are a touch closer to normal liver tissue -- like the addition of bile ducts -- and to see if they can mass produce them by the tens of thousands. Don't go wasting your liver just yet though, as it'll likely be years before the likes of you and me will be able to have a lab-grown liver in our bodies. In the meantime, check out the time-lapse video after the break to see a young liver bud take shape in a petri dish.



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